Restylane, Radiesse & Sculptra

How It Works

The Aging Process

Aging is a part of life, and as the years pass, the less vibrant, refreshed and youthful the skin may begin to look. In youthful skin, there is an abundance of collagen, elastin and hyaluronic acid which give it volume, support and suppleness. As a part of the aging process, these natural support structures become less plentiful. The result is facial lines, wrinkles and skin laxity - all of which rob the skin of its youthful, fresh appearance.

RESTYLANE

Restylane® was recently approved by the FDA for use in the United States and has been used in Europe and Canada for nearly a decade. It is an injectable gel, unlike Collagen, which is a paste composed of saline, local anesthesia, and the Collagen material itself. It is used for filling moderately deep wrinkles and depressions on the face and forehead.

Restylane consists of hyaluronic acid, a normal component of human skin, and is made synthetically using bacteria, then sterilized. It is not made out of other animals, so there is no need for allergy testing. It lasts longer than Collagen under equivalent circumstances. The pain of injection can be well controlled by using specific topical anesthetics.

Why choose RADIESSE® Volumizing Filler?

It is the only wrinkle filler that immediately replenishes lost volume and stimulates the production of your own natural collagen for long-lasting results.1,2,3
It is clinically proven to last a year or more in many patients 2,3
RADIESSE patients are significantly more satisfied than patients treated with other leading wrinkle fillers 2,4
It is FDA approved to mix with lidocaine, an anesthetic, to significantly reduce injection related pain

Wrinkle treatments with RADIESSE Volumizing Filler are quick and convenient, with immediately visible, long-lasting results. 2,3

Immediate results and natural collagen stimulation - it gets better with RADIESSE Volumizing Filler.1

RADIESSE® Volumizing Filler is comprised of Calcium Hydroxylapatite (CaHA) microspheres suspended in an aqueous gel carrier.1

Once injected, it provides immediate volume and correction but continues to work by stimulating the body to produce its own natural collagen.1

Over time, the gel is absorbed and the body metabolizes the CaHA microspheres leaving behind only your own natural collagen.1

Mechanism of Action

1 Berlin A, Hussain M, Goldberg D. (2008) Calcium Hydroxylapatite Filler (RADIESSE®) for Facial Rejuvenation: A Histologic and Immonohistochemical Analysis. Dermatologic Surgery, Volume 34, S64-S67.

2 Moers-Carpi M, Vogt S, et. Al (2007) A Multicenter, Randomized Trial Comparing Calcium Hydroxylapatite to Two Hyaluronic Acids for Treatment of Nasolabial Folds, Dermatologic Surgery, 33 (2S), 144s-151s.

3 Bass LS, Smith S, Busso M, McClaren M. (2010) Calcium Hydroxylapatite (RADIESSE) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results.

4 Moers-Carpi M, Tufet J. (2007) Calcium Hydroxylapatite versus Nonanimal Stabilized Hyaluronic Acid for the Correction of Nasolabial Folds: A 12-Month, Multicenter, Prospective, Randomized, Controlled, Split-Face Trial, Dermatologic Surgery, 2008; 34:210-215.

Smile Lines

For most of us, smile lines - also known as nasolabial folds - are nothing to smile about. These lines and creases run from the side of the nose to the corner of the mouth, and are the result of the loss of facial volume and skin elasticity as we age. They can make you look older, tired, or unhappy - even though you feel youthful inside. Fortunately, treatment with RADIESSE® Volumizing Filler can replenish youthful volume and stimulate collagen production in this area, minimizing the appearance of those pesky facial lines, wrinkles, and folds that mask our smiles. Best of all, results are clinically proven to last a year or more in many patients.1,2,3

Marionette Lines

Even if you have never heard of marionette lines, you probably know what they are. These lines that run straight downwards from the corners of the mouth can make you look unhappy. Marionette lines form as facial volume begins to deplete and deeper creases begin to form below the mouth.

Corners of the Mouth

The corners of the mouth, also known as the oral commissures, can turn downward as you age and lose volume below the mouth. This downturned appearance of the mouth can make you look like you are frowning or even mad. In addition, volume loss in this area often leads to the formation or the deepening of already-formed marionette lines.

Pre Jowl

A little known area of the face that can make a big impact on the way we look is the pre-jowl area, or the pre-jowl sulcus, which is the area on either side of our chin. Facial volume loss associated with the aging process results in sagging of the skin in other facial

areas, and leaves the pre-jowl area hollow

Chin wrinkle

This pesky wrinkle, forming horizontally across the chin can really distract from the smile. Caused by facial volume loss, chin wrinkles appear gradually over time.

Before and After

Treatment Areas

Questions and Answers

What is RADIESSE® Volumizing Filler?

RADIESSE® Volumizing Filler is an injectable wrinkle filler that works by immediately restoring facial volume to smooth out the signs of aging. Once injected, not only does it immediately add volume but over time, the Filler begins to stimulate the production of the body's natural collagen for results that may last up to a year or more in many patients.1,2,3

What is RADIESSE® Volumizing Filler made from?

It is made of tiny calcium-based microspheres suspended in a water-based gel. The calcium microspheres are similar to minerals found naturally in the body so allergy testing is not required. Over time, the body absorbs the microspheres and gel, leaving behind only natural collagen.1

Please note that RADIESSE Volumizing Filler is contraindicated in patients with severe allergies manifested by a history of anaphylaxis, with a history or presence of multiple severe allergies

How does RADIESSE® Volumizing Filler work?

Once injected, the Filler plumps the skin and replenishes volume lost over time for a more refreshed look. Over time, RADIESSE Volumizing Filler works to stimulate the body to produce collagen naturally.1 Ultimately the body absorbs the product and leaves behind the natural collagen for long-lasting results.2,3

What makes RADIESSE® Volumizing Filler different from other leading dermal fillers?

Itis the only dermal filler available composed of calcium-based microspheres, and is clinically proven to stimulate the natural production of collagen, for results that may last up to a year or more in many patients.1,2,3 Additionally, in clinical studies with leading hyaluronic acid injectable dermal fillers, results showed that RADIESSE patients were significantly more satisfied with their results than patients treated with other leading wrinkle fillers.2,4 In addition, 30% less Filler may be needed for correction when compared to Perlane® injectable gel.4

Where can RADIESSE® Volumizing Filler be injected?

RADIESSE Volumizing Filler can be injected in the following locations*:

Smile lines
Marionette lines
Corners of the mouth
Pre-jowl
Chin wrinkles

*RADIESSE Volumizing Filler is FDA-approved for correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.

How is treatment with RADIESSE® Volumizing Filler performed? Is it painful?

The Filler is injected under the skin in a safe and quick procedure that can be done over the lunch hour. RADIESSE Volumizing Filler is also FDA-approved to mix with lidocaine, which means the procedure will be much more comfortable. In fact, in a clinical study, 90% of patients treated reported significant pain reduction when injected with RADIESSE Volumizing Filler mixed with lidocaine.

What are the side effects of treatment with RADIESSE®Volumizing Filler?

As with any injection, patients may experience side effects such as mild irritation, swelling, itching, redness, bruising or tenderness at the injection site, which typically resolve on their own. If any of these side effects persist, contact your healthcare professional right away.

How soon will I see results with RADIESSE® Volumizing Filler, and how long will they last?

Immediately upon injection, RADIESSE Volumizing Filler restores volume to smooth out the signs of aging. The natural-looking results may last up to a year or more in many patients.2,3

Who can benefit from treatment with RADIESSE® Volumizing Filler?

RADIESSE Volumizing filler is FDA-approved for correction of moderate to severe wrinkles and folds. Talk to your doctor about what your specific treatment needs may be and to see if RADIESSE Volumizing Filler is right for you.

Is there anyone that should not use RADIESSE® Volumizing Filler?

RADIESSE Volumizing Filler should not be used in patients with severe allergies manifested by a history of anaphylaxis, a history or presence of multiple severe allergies or patients with known hypersensitivity to any of the components.

The safety of RADIESSE Volumizing Filler has not been established in patients who are pregnant or breastfeeding or under the age of 18. Patients using medications that can prolong bleeding, such as aspirin or warfarin, may, as with any injection, experience increased bleeding or bruising at the injection site.

OFFERING THE LATEST LONG LASTING FILLERS

Long-Lasting Youth

RADIESSE® Volumizing Filler does more than just fill troublesome lines, it immediately restores lost volume and stimulates the production of your own natural collagen - two things that other injectable fillers don't do.1 Best of all, results are clinically proven to last a year or more in many patients.2,3

RADIESSE Volumizing Filler takes the science of injectable fillers to the next level with the unique ability to immediately restore lost volume and stimulate the production of your body's own natural collagen.1 In worldwide clinical studies and actual patient use, RADIESSE Volumizing Filler has been proven to:

Stimulate natural collagen production 1
Immediately replenish lost volume for a more youthful appearance
Create results that last a year or more in many patients 2,3
Provide higher patient satisfaction than wrinkle treatment with other leading fillers 2,4

RADIESSE® Volumizing Filler: It Just Gets Better™

The best solution for erasing lines and folds is to replace lost structure with immediate volume. RADIESSE® Volumizing Filler works immediately so the results are instant. Once injected, RADIESSE Volumizing Filler adds the volume and lift needed to diminish the signs of aging. What makes RADIESSE truly unique is the ability of the product to act as a scaffold under the skin, providing structure and stimulating your own natural collagen to grow.1

The production of natural collagen continues for several months, which extends beyond the initial effect of RADIESSE Volumizing Filler.1 Best of all, the natural results are clinically proven to last a year or more in many patients, which means more value from each treatment and long-lasting results.2,3